Figure 5.

Ionic crosslinked bioink for skin bioprinting. (A) Schematic of the inkjet-spray printing process for the fabrication of laminated hydrogel structures. (B) Inkjet-spray-printed hydrogel structures of various scales, ranging from several hundreds of micrometers to a few tens of centimeters. The results indicated a high cell viability on the hydrogel structure. Reproduced with permission from [93]; copyright Wiley-VCH, 2018. (C) The optical image (Left) and optical cross-section image stained with hematoxylin and eosin (Right) of the fabricated core/shell scaffold. (D) The optical image (Left) and histological photomicrograph of the wound cross-section. Arrowheads indicate the generated vasculature. Reproduced with permission from [150]; copyright Royal Society of Chemistry, 2011. (E) Representative image (Left) of the cell-laden printed construct and fluorescence image (Right) of cells embedded in the printed construct. (F) Sweat gland regeneration (Middle) and histology of wound healing (Right) in mouse paw after 3D-ECM mimics implantation; the burned mouse paw is shown on the left. Reproduced with permission from [82]; copyright Elsevier, 2015.