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In vitro performance of Rif-HApN against Sa. (a) Macroscopic pictures of the zones of inhibition (ZOIs) developed by Rif-HApN in the agar plates at selected time-points (days 1, 4 and 6). As expected, drug-free HApN did not exert any antibacterial activity. (b) Measurement of the ZOIs revealed a strong, sustained antibacterial effect of the meshes coated with the Rif-HApN hydrogel (n = 3) that lasted for 5 days.
