Table 2.

Total analysis of seven KCNQ1 gene polymorphisms on T2DM risk.

Variables	N a	Cases/controls	Allelic comparison				Homozygote comparison				Heterozygote comparison				Dominant genetic model				Recessive genetic model
			OR (95% CI)	P b	I 2 (%)	P c	OR (95% CI)	P b	I 2 (%)	P c	OR (95% CI)	P b	I 2 (%)	P c	OR (95% CI)	P b	I 2 (%)	P c	OR (95% CI)	P b	I 2 (%)	P c
rs2237892	42	50,747/50,023	1.23(1.14, 1.33)	<0.01	88.7	<0.01	1.69(1.45, 1.96)	<0.01	80.2	<0.01	1.40(1.28, 1.54)	<0.01	44.3	<0.01	1.55(1.37, 1.76)	<0.01	71.9	<0.01	1.24(1.12, 1.36)	<0.01	87.7	<0.01
rs2237895	23	42,127/38,276	1.21(1.16, 1.27)	<0.01	74.1	<0.01	1.45(1.32, 1.60)	<0.01	70.7	<0.01	1.23(1.17, 1.29)	<0.01	48.6	0.01	1.28(1.21, 1.36)	<0.01	65.9	<0.01	1.31(1.22, 1.41)	<0.01	56.9	<0.01
rs2237897	12	18,808/18,847	1.27(1.11, 1.46)	<0.01	92.5	<0.01	1.49(1.09, 2.03)	0.01	91.6	<0.01	1.19(0.96, 1.48)	0.11	84.2	<0.01	1.34(1.02, 1.74)	0.03	91.2	<0.01	1.36(1.16, 1.60)	<0.01	88.7	<0.01
rs2283228	10	13,188/12,191	1.25(1.09, 1.42)	<0.01	81.8	<0.01	1.53(1.25, 1.87)	<0.01	50.3	0.03	1.20(1.08, 1.33)	<0.01	0.0	0.90	1.33(1.18, 1.49)	<0.01	10.9	0.34	1.30(1.10, 1.55)	<0.01	83.2	<0.01
rs231362	9	7666/6626	1.16(0.83, 1.61)	0.39	94.7	<0.01	1.51(0.90, 2.53)	0.12	77.1	<0.01	1.22(0.94, 1.58)	0.14	24.5	0.23	1.33(0.90, 1.97)	0.15	65.1	<0.01	1.22(0.82, 1.8)	0.33	94.6	<0.01
rs151290	9	7808/7836	1.14(1.03, 1.27)	0.02	71.2	<0.01	1.35(1.09, 1.66)	<0.01	61.6	0.01	1.20(1.04, 1.38)	0.01	27.5	0.20	1.26(1.08, 1.47)	<0.01	41.1	0.09	1.18(1.02, 1.37)	0.03	73.5	<0.01
rs2074196	5	11,019/11,672	1.31(1.23, 1.39)	<0.01	39.7	0.16	1.75(1.54, 1.99)	<0.01	26.7	0.24	1.33(1.22, 1.46)	<0.01	0.0	0.50	1.51(1.37, 1.66)	<0.01	6.4	0.37	1.37(1.27, 1.49)	<0.01	39.9	0.16

CI: confidence interval; T2DM: type 2 diabetes mellitus. ^aNumber of comparisons. ^bP value of Z-test for the significant test. ^cP value of Q-test for the between-study heterogeneity test.