Table 3.
Electrophysiologic studies and neurologic examinations of patients by DSPN stagea with mMNSI < 2.5 or ≥2.5.
| No DSPN | Minimal DSPN | Subclinical DSPN | DSPN | ||||
|---|---|---|---|---|---|---|---|
| All DSPN | Mild DSPN | Moderate DSPN | Severe DSPN | ||||
| Total | |||||||
| Patient no. | 64 | 19 | 18 | 44 | 18 | 14 | 12 |
| Symptoms of polyneuropathy, n (%) | 12 (18.8) | 4 (21.1) | 11 (61.1)∗∗∗ | 32 (72.7)∗∗∗ | 12 (66.7) | 11 (78.6) | 9 (75.0) |
| Reduction of ankle reflex, n (%) | 40 (62.5) | 19 (100.0)∗∗ | 14 (77.8) | 43 (97.7)∗∗∗ | 17 (94.4) | 14 (100.0) | 12 (100.0) |
| Bilateral median neuropathy at wrists, n (%) | 26 (40.6) | 8 (42.1)∗ | 13 (72.2) | 27 (61.4)∗ | 10 (55.6) | 11 (78.6) | 6 (50.0) |
| Abnormal thermal test, n (%) | 6 (9.4) | 16 (84.2)∗∗∗ | 0 (0.0) | 40 (90.9)∗∗∗ | 15 (83.3) | 14 (100.0) | 11 (91.7) |
| Abnormal vibration, n (%) | 0 (0.0) | 4 (21.1)∗∗∗ | 2 (11.1) | 24 (54.5)∗∗∗ | 9 (50.0) | 8 (57.1) | 7 (58.3) |
| mMNSI < 2.5 | |||||||
| Patient no. | 64 | 0 | 18 | 0 | 0 | 0 | 0 |
| Symptoms of polyneuropathy, n (%) | 12 (18.8) | — | 11 (61.1) | — | — | — | — |
| Reduction of ankle reflex, n (%) | 24 (37.5) | — | 4 (22.2) | — | — | — | — |
| Bilateral median neuropathy at wrists, n (%) | 26 (40.6) | — | 13 (72.2) | — | — | — | — |
| Abnormal thermal test, n (%) | 6 (9.4) | — | 0 (0.0) | — | — | — | — |
| Abnormal vibration, n (%) | 0 (0.0) | — | 2 (11.1) | — | — | — | — |
| mMNSI ≥ 2.5 | |||||||
| Patient no. | 0 | 19 | 0 | 44 | 18 | 14 | 12 |
| Symptoms of polyneuropathy, n (%) | — | 4 (21.1) | — | 32 (72.7) | 12 (66.7) | 11 (78.6) | 9 (75.0) |
| Reduction of ankle reflex, n (%) | — | 0 (0.0) | — | 43 (97.7) | 17 (94.4) | 14 (100) | 12 (100) |
| Bilateral median neuropathy at wrists, n (%) | — | 8 (42.1) | — | 27 (61.4) | 10 (55.6) | 11 (78.6) | 6 (50.0) |
| Abnormal thermal test, n (%) | — | 16 (84.2) | — | 40 (90.9) | 15 (83.3) | 14 (100.0) | 11 (91.7) |
| Abnormal vibration, n (%) | — | 4 (21.1) | — | 24 (54.4) | 9 (50.0) | 8 (57.1) | 7 (58.3) |
Abbreviations: mMNSI: modified Michigan Neuropathy Screening Instrument; DSPN: distal symmetrical polyneuropathy; DPNP: diabetic peripheral neuropathic pain; NCS: nerve conduction studies. aNo DSPN, patients with mMNSI total score < 2.5 and NCS severity score 0-1; minimal DSPN, patients with mMNSI total score≧2.5 and NCS severity score 0-1; subclinical DSPN, patients with mMNSI total score < 2.5 and NCS severity score≧2; DSPN, patients with mMNSI total score≧2.5 and NCS severity score≧2. Data were compared with DSPN stage, no DSPN using the chi-squared test. ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.0001 indicate significant difference as compared with no DSPN.