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. Author manuscript; available in PMC: 2020 Jul 15.
Published in final edited form as: Nature. 2018 Aug 22;561(7722):258–262. doi: 10.1038/s41586-018-0448-9

Figure 1. Inflammation and mitophagy with Parkin and PINK1 deficiency.

Figure 1.

a) pS65-ubiquitin as a percentage of total ubiquitin (right y-axis) and as fmol per mg total protein (left y-axis) from heart tissue (n=6). b) Representative images of heart tissue from SED or EE mice expressing mtKeima with quantification of the 561nm/488nm ratio (n=3). c) Representative images of heart tissue from wild type and PINK1−/− EE mice expressing mt-Keima with quantification of the 561nm/488nm ratio (n=3). d-e) Serum IL-6 and IFNβ1 concentrations for EE mice (n=10). Graphs are presented as mean−/+SD. ****, **, * indicate P<0.001, 0.01, 0.05. ns=not significant.