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. Author manuscript; available in PMC: 2020 Jul 15.
Published in final edited form as: Nature. 2018 Aug 22;561(7722):258–262. doi: 10.1038/s41586-018-0448-9

Figure 4. STING loss prevents inflammation, a motor defect and neurodegeneration in the Parkin−/−;Mutator mice.

Figure 4.

a, b) Serum IL-6 and IFNβ1 concentrations from 12-, 20-, and 40-week-old mice (n=4, 6). c) Venn diagram depicting serum cytokines found here elevated in each paradigm and those reported in idiopathic human patients (grey)1. d) The average time required for mice to descend the pole (n=6). e) TH+-neurons counted by stereology in the substantia nigra (SNc) of 40-week-old mice (n=3, 4). f) Representative images of TH+-neurons (green) and total neurons (NeuN, red). Graphs are presented as mean−/+SD. ****, ***, **, indicate P<0.001, 0.005, 0.01. ns=not significant.