Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jul 14;17:210. doi: 10.1186/s12974-020-01887-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 2 — Downregulation of BDNF and TrkB in aged microglial cells. a–b Representative dual immunofluorescent images show the distribution of BDNF (a) and TrkB (c) in the Iba1⁺ cells in the SN of 6- and 12-month-old mice. Scale bar: 10 μm. The percent areas of BDNF⁺Iba1⁺/Iba1⁺ (b) and TrkB⁺Iba1⁺/Iba1⁺ (d) in the SN of 6- and 12-month-old mice. BDNF⁺ areas were detected from 31 cells in three 6-month-old mice and 56 cells in three 12-month-old mice; TrkB⁺ areas were obtained from 35 cells in three 6-month-old mice and 73 cells in three 12-month-old mice. ***p < 0.001 versus 6-month-old mice. e–h Correlations (Pearson) between the levels of BDNF and TrkB, and the area and number of Iba1⁺ cells (n = 24)