Table 3.
Hub genes with high degree of connectivity in each module
| Category | MCODE module | Gene symbol | Degree | Type | Full name | Go BP ID | KEGG pathways |
|---|---|---|---|---|---|---|---|
| NPDEG | Module 1 | HLA-DRA | 7 | Up | Major histocompatibility complex, class II, DR alpha | GO:0002478, GO:0019884, GO:0019886, GO:0048002, GO:0002495, GO:0002504, GO:0019882, GO:0060333, GO:0002429, GO:0071346, GO:0002768, GO:0034341, GO:0050852, GO:0002503, GO:0050851, GO:0002399, GO:0002501, GO:0002396, | hsa04940, hsa05310, hsa05330, hsa05332, hsa05150, hsa05322, hsa04672, hsa05140, hsa04612, hsa04145, hsa05320, hsa05416, hsa05323, hsa05152, hsa04640, hsa05321, hsa04514, hsa04658, hsa04659, hsa05145, hsa05166, hsa05164, hsa05169 |
| PMDEG | Module 1 | CDK1 | 74 | Up | Cyclin dependent kinase 1 | GO:0010038, GO:1901988, GO:0045930, GO:1901991, GO:0010948, GO:0007093, GO:0007568, GO:0046677, GO:0031145, GO:0000075, GO:0042692, GO:0009123, GO:0009141, GO:0071103, GO:0045927, | hsa04110 |
| PMDEG | Module 1 | CDK20 | 62 | Up | Cyclin dependent kinase 20 | / | / |
| PMDEG | Module 1 | CCNB1 | 61 | Up | Cyclin B1 | GO:0140014, GO:0000819, GO:0000070, GO:0010038, GO:0000280, GO:0007059, GO:0048285, GO:0045839, GO:0098813, GO:0007088, GO:0051784, GO:0051783, GO:0001701, GO:0010965, GO:2000816, GO:0051983, GO:1905819, GO:0051306, GO:0030071, GO:0033048, GO:1905818, GO:0007094, GO:0031577, GO:0071173, GO:0071174, GO:0033044, GO:1902099, GO:0071241, GO:0033046, GO:0007091, GO:0051985, GO:1901988, GO:0045841, GO:0051304, GO:0044784, GO:0071248, GO:1902100, GO:0033047, GO:0033045, GO:0045930, GO:0070482, GO:1901991, GO:0010948, GO:0007093, GO:0036293, GO:0001666, GO:0031145, GO:0051656, GO:0000075, GO:0071453, GO:0042692, GO:0009123, GO:0009141, GO:0048565, GO:0010639, GO:0071103, GO:0045927 | hsa04110 |
| PMDEG | Module 2 | MTIF2 | 25 | Up | Mitochondrial translational initiation factor 2 | GO:0032543, GO:0140053 | / |
| PMDEG | Module 2 | MRPS7 | 25 | Down | Mitochondrial ribosomal protein S7 | GO:0032543, GO:0140053, GO:0070125, GO:0006414, GO:0022613, GO:0070126 | / |
| PMDEG | Module 3 | VEGFA | 38 | Down | Vascular endothelial growth factor A | GO:0043129, GO:0052547, GO:0048875, GO:0052548, GO:0050900, GO:0010466, GO:0010951, GO:0032103, GO:0010810, GO:0045785, GO:0048732, GO:0001701, GO:0010811, GO:0060249, GO:0033044, GO:0031589, GO:0045807, GO:0097529, GO:0045861, GO:0030595, GO:0070482, GO:0048871, GO:0051346, GO:0036293, GO:0001666, GO:0002576, GO:0001894, GO:0002685, GO:0002688, GO:0060627, GO:0071453, GO:0001954, GO:0042692, GO:0001952, GO:0050920, GO:0030100, GO:0060326, GO:0050678, GO:0002687, GO:0061138, GO:0016049, GO:0045927 | hsa05323, hsa04510, hsa04933 |
| PMDEG | Module 3 | EGF | 34 | Up | Epidermal growth factor | GO:0140014, GO:0043129, GO:0052547, GO:0043062, GO:0030198, GO:0000280, GO:0048875, GO:0052548, GO:0048285, GO:0007088, GO:0050900, GO:0010466, GO:0010951, GO:0032103, GO:0010810, GO:0045785, GO:0048732, GO:0051783, GO:0001701, GO:0010811, GO:0060249, GO:0033044, GO:0031589, GO:0045807, GO:0097529, GO:0045861, GO:0030595, GO:0070482, GO:0048871, GO:0051346, GO:0036293, GO:0001666, GO:0002576, GO:0001894, GO:0002685, GO:0002688, GO:0045862, GO:0060627, GO:0071453, GO:0001954, GO:0042692, GO:0007219, GO:0001952, GO:0050920, GO:0030100, GO:0060326, GO:0050678, GO:0051098, GO:0002687, GO:0061138, GO:0016049, GO:0045927 | hsa04668, hsa05323, hsa04510, hsa04933 |
/: no significant related GO BP or KEGG pathway term