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. 2020 Jul 15;12:63. doi: 10.1186/s13073-020-00760-3

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — ASXL3 defines a subtype of SCLC with high expression of ASCL1. a Schematic of three BAP1 complexes, which is defined by 3 different additional sex-combs-like proteins ASXL1, ASXL2, and ASXL3. b The counts per million (CPM) value for ASXL1/2/3 expression in 1004 human cell lines. c The log2 (fold-change) heatmaps show the global gene expression profile in ASXL3-high (CPM > 5000) and ASXL3-low (CPM < 500) SCLC cell lines. d The PCA plot analysis indicated that the ASXL3-high and ASXL3-low cell lines are separated into two distinctive groups of SCLC cell types. e The gene expression enrichment analysis shows the most enriched genes in ASXL3-high and ASXL3-low SCLC cell lines. f The box plot shows the expression level of ASXL1, ASXL2, and ASXL3 between ASCL1-high and ASCL1-low SCLC cell lines. P value is calculated based on the t test. g The scatter plot shows the correlation between ASXL3-associated genes and ASCL1-associated genes via log2 fold-change