Table 1.
Outcome of retrospective studies on radiotherapy for lentigo maligna and lentigo maligna melanoma
| First author | Year | Center | Period | Sample size | Local recurrence rate | Complete response rate | Follow-up duration | Cosmetic results | Notes |
|---|---|---|---|---|---|---|---|---|---|
| Lazarevic [10] | 2019 | Zurich, Switzerland | 2009–2014 | 27 LM, 18 M | 15% (LM), 17% (M) | n.a. | 51 months (mean) | «good» | periocular lesions, 44% of melanoma patients with immunosuppression, 11% LM |
| Lamoureux [11] | 2018 | Bordeaux, France | 2007–2017 | 42 LM, 6 LMM, 13 LMM with previous surgery | 10% (overall), 7% (only LM) | n.a. | 22 months (mean), range 3–70 months | 9.8% hypopigmentation, 8.1% teleangiectasia, no fibrosis | Conference abstract only |
| Hedblad [12] | 2012 | Stockholm, Sweden | 1990–2009 | 593 LM or early LMM; 59% primary RT; 12% after partial excision, 29% adjuvant RT after complete excision | Overall 12% (17% primary RT, 9% RT after partial excision, 3% RT after complete excision) | 88% (primary RT); 90% (RT after partial excision); 97% (RT after complete excision) | 425 patients for at least 24 months, 241 for more than 60 months | «excellent» (15% hypopigmentation, 20% hyperpigmentation, «some» teleangiectasia) | 86% facial localization |
| Lee [13] | 2011 | London, Ontario, Canada | 1991–2005 | 31 LM | 29% (LM) | n.a. | 46.3 months (median) | 19.4% teleangiectasia, 6.5% hypopigmentation | 89.3% head and neck region |
| Zalaudek [14] | 2003 | Graz, Austria | 1990–2000 | 15 LM | 13% (LM) | n.a. | 5-year recurrence rate reported | n.a. | All lesions in head and neck region |
| Farshad [15] | 2002 | Zurich, Switzerland | 1950–2000 | 93 LM, 54 LMM, 3 LM and LMM (more than one lesion in 4%) | 7% overall, (for 101 patients with a follow-up of at least 2 years) | n.a. | 8 years (mean) | «acceptable» | 90% facial localization |
| Schmid-Wendtner [16] | 2000 | Munich, Germany | 1987–1998 | 42 LM, 22 LMM | 0% (LM), 9% (LMM) | n.a. | 15 months (median, range 1–96) | “good or excellent”, no ulcers or fibrosis | 98% head and neck region |
| Christie [17] | 1996 | Westmead, Australia | 1989–1995 | 5 LM | 0% (LM) | 100% (LM) | 16 months (median, range 8–37 months | «favourable», teleangiectasia in 2 patients | All lesions in head and neck region |
| Tsang [18] | 1994 | Toronto, Ontario, Canada | 1968–1988 | 36 LM | 11% (LM) | n.a. | 72 months (median) | «acceptable», «poor» in 11% (skin pallor, atrophy, teleangiectasia) | 18 patients already included in previous publication [19]; 92% head and neck area |
| Harwood [19] | 1983 | Toronto, Ontario, Canada | 1958–1982 | 23 LM, 28 LMM | 10% (LM), 8% (LMM) | n.a. | LM: (26 months (median, range 5–96 months); LMM: 24 months (median, range 6–96 months) | n.a. | 96% head and neck region |
| Richter [20] | 1977 | Dresden, Germany | 1957–1975 | 12 LM, 5 LMM | 0% | 100% | 12–84 months | “excellent” | 79% head and neck region; publication in German |
| Kopf [21] | 1976 | New York, USA | 1964–1973 | 16 LM | 31% | 94% | median: 32.5 months (range 6–113) | “fair to excellent” in most cases | |
| Braun-Falco [22] | 1975 | Munich, Germany | 1955–1970 | 68 LM | 0% (LM) | 100% (LM) | 36 months (mean, range 12–120 months) | «good» | 86% facial or head area; histological diagnosis only in 10 cases; publication in German |
| Arma-Szlachcic [23] | 1970 | Zurich, Switzerland | 1941–1965 | 69 LM, 19 LMM | 3% (LM), 0% (LMM, but metastatic spread in 26%) | 100% (LM) | at least 60 months in 74 patients | n.a. | 84% facial localization; publication in German |
LM Lentigo maligna; LMM Lentigo maligna melanoma; M Melanoma (not further specified); n.a. Not available; RT Radiotherapy