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. 2020 Jul 14;8:17. doi: 10.1186/s40170-020-00223-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Growth inhibition of ErbB2 breast cancer cells by MEDICA. a–d Human ErbB2 AU565and BT474 cells, mouse ErbB2 RH2111 cells, and non-tumorigenic MCF10 cells were treated with MEDICA as indicated. a Cell growth. Mean ± SD. b Anchorage-dependent colonies. c Anchorage-independent colonies. d BT474 spheroids were allowed to form for 24 h followed by treatment for 8 days with MEDICA. Medium was refreshed every 3 days. Spheroid viability assayed by acid phosphatase was inhibited by 90% at 175 μM MEDICA. e Growth (72 h) inhibition of trastuzumab-resistant ErbB2 BT474 cells by MEDICA (left). Resistance was confirmed by growth with increasing trastuzumab concentrations as indicated (right). Mean ± SD. *Significant as compared to control (P < 0.05). f Cell cycle (24 h) suppression of AU565 cells by 200uM MEDICA. Mean ± SD. *Significant as compared to control (P < 0.05). Inset—representative micrographs