Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jul 14;8:17. doi: 10.1186/s40170-020-00223-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 5 — Mitochondria targeting by MEDICA. a Oxygen consumption rate (OCR) was determined in AU565 cells in the presence of 30 μM MEDICA as described in the “Methods” section. Representative chart. b Enzymatic activities of mitochondrial ETC complexes were measured in mouse brain mitochondria in the absence (denoted as 1.0) and presence of 200 μM MEDICA. CI, complex I; CII, complex II; CIII, complex III; CIV, complex IV; Fe-CI, Ferricyanide reductase; SDH, succinate dehydrogenase. Mean of 2–3 determinations. c ATP levels were determined in AU565 cells treated for 24 h with 200 μM MEDICA. Mean ± SD. *Significant as compared to control (P < 0.05). d Mitochondrial superoxide formation was determined in AU565 cells treated for 6 h with 200 μM MEDICA and/or 0.4 μM methylene blue (MB) as indicated. Mean ± SD. *Significant as compared to control (P < 0.05). e Mitochondrial superoxide formation was determined in BT474 cells infected with empty or NDI1 virus and treated for 6 h with 200 μM MEDICA as indicated. Mean ± SD. *Significant as compared with respective control (P < 0.05). **Significant as compared with empty plasmid (P < 0.05)