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. 2020 Jul 14;8:17. doi: 10.1186/s40170-020-00223-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Rescue of MEDICA effects by NDI1. a ErbB members and Akt were measured in BT474 cells infected with empty or NDI1 virus and cultured in galactose. Cells were treated for 40 h with MEDICA as indicated. Representative blots. b mTORC1 downstream targets were measured in BT474 cells infected with empty or NDI1 virus. Cells were treated for 24 h with MEDICA as indicated. Representative blots. c Inhibition of ErbB signaling and mTORC1 by MEDICA is partly rescued by infected NDI1. Conditions as in a and b. Mean ± SD. *Significant as compared to respective control (P < 0.05). ^#Significant as compared to empty virus (P < 0.05). d BT474 cells infected with empty or NDI1 virus were cultured in galactose medium and treated for 72 h with MEDICA as indicated. Mean ± SD. *Significant as compared to empty virus (P < 0.05). e BT474 spheroids prepared from cells infected with empty or NDI1 virus were allowed to form for 4 days followed by treatment for 8 days with MEDICA or phenformin as indicated. *Significant as compared to respective control (P < 0.05). ^#Significant as compared to empty virus (P < 0.05)