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. 2020 Jul 15;39:135. doi: 10.1186/s13046-020-01634-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — THOC1 promotes HCC cell proliferation and cell cycle progression. a Knockdown or ectopic expression efficiency of THOC1 and the expression of proliferation markers were evaluated via Western blot analysis. b Cell growth was inhibited by THOC1 knockdown in PLC/PRF/5 and Hep3B cells (left panel), whereas cell viability was dramatically increased by the ectopic expression of THOC1 in HepG2 and SK-Hep1 cells (right panel) (Student’s t test; **P < 0.01, ***P < 0.001, ****P < 0.0001). c Knockdown of THOC1 inhibited the colony formation in PLC/PRF/5 and Hep3B cells (Student’s t test; **P < 0.05). d Ectopic expression of THOC1 increased the colony formation in HepG2 and SK-Hep1 cells (Student’s t test; **P < 0.05). e Cell cycle assay was conducted after THOC1 knockdown in PLC/PRF/5 and Hep3B cells, where the proportion of different cell cycle phases was shown and statistically analyzed (Student’s t test; *P < 0.05, **P < 0.01). f Cell cycle assay was performed after the ectopic expression of THOC1 in HepG2 and SK-Hep1 cells, where the proportion of cell cycle phases was shown and statistically analyzed (Student’s t test; **P < 0.01)