Table 1.
Comparison of the baseline and the clinical characteristics between the patients with vitamin B1 and C and those without
| Variable | Total (n=79) | Vitamin B1 and C (n=33) | No vitamin (n=46) | p-value |
|---|---|---|---|---|
| Age, yr | 70 (59–79) | 66 (55.5–81) | 73.5 (63–79) | 0.257 |
| Male sex | 54 (68.4) | 20 (60.6) | 34 (73.9) | 0.210 |
| BMI, kg/m2 | 21.8 (20.1–24.9) | 22.5 (20.7–26.2) | 21.6 (19.7–24.2) | 0.179 |
| Diabetes mellitus | 23 (29.1) | 10 (30.3) | 13 (28.3) | 0.844 |
| Chronic kidney disease | 7 (8.9) | 4 (12.1) | 3 (6.5) | 0.443 |
| Chronic liver disease | 12 (15.2) | 5 (15.2) | 7 (15.2) | 0.994 |
| Cerebrovascular disease | 14 (17.7) | 4 (12.1) | 10 (21.7) | 0.270 |
| Active malignancy | 7 (8.9) | 1 (3.0) | 6 (13) | 0.229 |
| COPD | 5 (6.3) | 3 (9.1) | 2 (4.3) | 0.644 |
| APACHE II | 27 (23–33) | 26 (20.5–32.5) | 30 (24–33.3) | 0.226 |
| SOFA | 13 (10–15) | 13 (11–15) | 12 (10–14.3) | 0.462 |
| Cause of sepsis | 0.671 | |||
| Pneumonia | 73 (92.4) | 30 (90.9) | 43 (93.5) | |
| Pancreatico-biliary origin | 4 (5.1) | 1 (3) | 3 (6.5) | |
| Others | 2 (2.5) | 2 (6.1) | ||
| Septic shock | 57 (72.2) | 21 (63.6) | 36 (78.3) | 0.153 |
| AKI | 47 (59.5) | 18 (54.5) | 29 (63) | 0.448 |
| RRT | 20 (25.3) | 7 (21.2) | 13 (28.3) | 0.477 |
| MV parameters | ||||
| TV (PBW), mL/kg | 7.4 (6.2–8) | 7.5 (6.4–8.5) | 7.1 (6.1–7.9) | 0.272 |
| PEEP | 8 (5–10) | 7 (5–10) | 8 (5.8–10.5) | 0.071 |
| FiO2 | 80 (60–100) | 80 (70–100) | 80 (60–92.5) | 0.295 |
| Use of NM blockers | 25 (31.6) | 18 (54.5) | 7 (15.2) | <0.001 |
| Steroid | 39 (49.4) | 23 (69.7) | 16 (34.8) | 0.002 |
| Prone position | 11 (13.9) | 8 (24.2) | 3 (6.5) | 0.045 |
| ECMO | 4 (5.1) | 2 (6.1) | 2 (4.3) | 1.000 |
BMI: body mass index; COPD: chronic obstructive pulmonary disease; APACHE: Acute Physiology and Chronic Health Evaluation; SOFA: Sequential Organ Failure Assessment; AKI: acute kidney injury; RRT: renal replacement therapy; MV: mechanical ventilation; TV: tidal volume; PBW: predicted body weight; PEEP: positive end-expiratory pressure; FiO2: fractioned inspired oxygen; NM: neuromuscular blocking; ECMO: extracorporeal membrane oxygenation.