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. 2020 Jul 3;8:281. doi: 10.3389/fpubh.2020.00281

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Copyright © 2020 Torequl Islam, Nasiruddin, Khan, Mishra, Kudrat-E-Zahan, Alam Riaz, Ali, Rahman, Mubarak, Martorell, Cho, Calina, Docea and Sharifi-Rad.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Summarized scheme with proposed acting targets of anti-SARS-CoV-2 in the replication cycle of the virus. Inhibitors of cell entry: inhibitors of angiotensin-converting enzyme 2 (ACE2Is) and antimalarial drugs: chloroquine, hydroxychloroquine; inhibitors of transmembrane protease/serine subfamily member 2 (TMPRSS2): camostate; Inhibitors of replication, membrane fusion, and assembly of SARS-CoV-2: remdesivir, lopinavir/ritonavir combination, umifenovir; humanized monoclonal antibody IgG1 anti-human receptor for interleukin-6 (IL-6): tocilizumab.

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