Table 1.
List of patients operated on with the additional use of the MFL-technique.
| Patient-Nr. | Gender | Age at operation | Tumor entity | Tumor location | Primary tumor or mutation status | Fluorescence quality | Postoperative new neurological deficit | MRI- contrast enhanced resection |
|---|---|---|---|---|---|---|---|---|
| 1 | F | 71 | Metastasis | Left parietal | Adeno-ca lung | Capsule intensive, content barely | None | Complete |
| 2 | F | 59 | Metastasis | Right temporal | Sigma-ca GI tract | Very intensive | None | Complete |
| Metastasis | Right parietal | Sigma-ca GI tract | Very intensive | None | Complete | |||
| 3 | F | 83 | Metastasis | Right cerebellar | Adeno-ca lung | Intensive but inhomogeneous | None | Complete |
| 4 | M | 63 | Metastasis | Right parietal | Large cell ca lung | Very intensive | None | Complete |
| 5 | M | 41 | Anaplastic Astrocytoma | Right parietal | IDH-mutate, MGMT + | Very intensive | None | Minimal rest near postcentral |
| 6 | F | 72 | GBM cystic | Right temporal | IDH-mutate, MGMT + | Cyst very intensive, content barely | None | Minimal ependymal rest around the ventricle wall |
| 7 | F | 75 | Meningioma WHO I | Left frontal | Very intensive | None | Complete | |
| 8 | M | 50 | Anaplastic Oligodendroglioma | Right frontal | MGMT + | Very intensive | None | Complete |
| 9 | M | 56 | Metastasis | Right frontal | Adeno-ca lung | Very intensive | None | Complete |
| 10 | M | 53 | GBM | Right temporal | IDH-wild type, MGMT + | Very intensive | None | Complete |
| 11 | M | 77 | Metastasis | Right frontal | Sigma-ca GI tract | Very intensive | None | Complete |
| 12 | F | 77 | Meningioma WHO I | Right parietal | Very intensive | None | Complete | |
| 13 | F | 51 | Acoustic Neuroma | Right cerebelo-pontine angle | Intensive but inhomogeneous | Hypakusis | Complete | |
| 14 | M | 73 | GBM | Right frontal | MGMT − | Very intensive | None | Complete |
| 15 | M | 62 | GBM | Right parieto-occipital | IDH-wild type, MGMT − | Very intensive | None | Minimal rest in the calcarine sulcus |
| 16 | M | 44 | Anaplastic Astrocytoma | Left trigonum, thalamus, midbrain | IDH-wild type, MGMT − | Very intensive | None | Incomplete resection due to midbrain thalamus infiltration |
| 17 | M | 63 | Metastasis | 4th ventricle | Adeno-ca lung | Very intensive | Diziness | Complete |
| 18 | M | 73 | GBM | right frontal | IDH-wild type, MGMT − | Very intensive | None | No MRI postop |
| 19 | M | 50 | Ependymoma WHO II | 4th ventricle | Very intensive | None | Complete | |
| 20 | M | 51 | Metastasis | Spinal | Myxoid liposarcoma | Intensive but inhomogeneous | None | Complete |
| 21 | F | 78 | Metastasis | Left temporal | Squamous tongue ca | Very intensive | None | Complete |
| 22 | F | 32 | Anaplastic Astrocytoma | Left frontal precentral | IDH-mutate, MGMT + | Very intensive | None | Complete |
| 23 | M | 65 | Anaplastic Astrocytoma | Left frontal precentral | IDH-mutate, MGMT + | Very intensive | None awake surgery | Complete |
| 24 | F | 76 | GBM | Right frontal precentral | IDH-wild type, MGMT + | Very intensive | Hemiparesis arm 4/5 | Minimal rest precentral, intraoperative monitoring +++ |
| 25 | F | 63 | Metastasis | Right frontal | Breast-ca | Very intensive | None | Complete |
Ca = Carcinoma, GBM = Glioblastoma, GI = gastrointestinal, IDH = isocitrate dehydrogenase, M = male, MGMT = O6-methylguanine DNA methyltransferase, F = female.
In patient number 2, two different craniotomies had to be performed as the tumor was metastasized into both the temporal and parietal lobe. Patient 10 in this table is described in case vignette #1, patient 23 in case vignette #2 and patient 21 in case vignette #3.