Table 1.
Symbol | Definition (units) | Sampled parameter(s) | Prior [Truncation] | Notes |
---|---|---|---|---|
Pop | Population size | Input (not sampled) | Constant | 31 |
Ninit | Initial IU on 2020-02-29 | Ninit | LogN(1000, 10) [1, 10000] | ¶ |
1/α | Self-isolation time after contact tracing | Tisolation = 1/α | LogN(14, 2) [7, 21] | † |
1/κ | Latent period (d) | Tlatent = 1/κ | N(4,1) [2,7] | 32,33 |
c0 | Baseline contact rate (contacts d−1) | c0 | N(13, 5) [7, 20] | 34 |
ρ | Recovery rate (d−1) | Trecover = 1/ρ | LogN(10, 1.5) [5, 30] | 33,35 |
β0 | Transmission rate (d−1) | R0 = c0β0/ρ | N(2.9, 0.78) [1.46, 4.5] | 36-38 |
fC | Fraction of contacts traced (unitless) | fC | LogN(0.25, 2) [0.15, 1] | 39 |
TT | Date of startup of testing (d) | TT | N(70, 10) [60, 90] | ¶ |
λ | General positive diagnosis rate (d−1) | λ = Ftest Senstest ktest | Derived | 36,40,41 |
Ftest | General test coverage (unitless) | Ftest | N(0.5, 0.2) [0.2, 0.8] | 36,40,41 |
Senstest | Test sensitivity (unitless) | Senstest | N(0.7, 0.1) [0.6, 0.95] | 42 |
ktest | General testing rate (d−1) | τtest = 1/ktest | N(7, 3) [2, 12] | 43,44 |
λC | Contacts positive diagnosis rate (d−1) | λC = Senstest ktest,C | Derived | |
kC,test | Contacts testing rate (d−1 | τC,test = 1/kC,test | N(2, 1) [1, 3] | ¶ |
ρC | Rate of infected contacts testing negative (d−1) | ρC = (1 – Senstest) ktest,C | Derived | |
δ | Fatal illness rate (d−1) | IFR (infected fatality rate)* | LogN(0.01, 2) [0.001, 0.1] | 35,45 |
θmin | Minimum of θ(t) | θmin | Validation: Beta(2,2) Calibration: State-specific |
¶
ƣ |
τθ | Weibull scale parameter | τθ | Validation: N(21, 7) [7, 35] Calibration: State-specific |
¶
ƣ |
nθ | Weibull shape parameter | nθ | Validation: LogN(6, 2) [1,11] Calibration: State-specific |
¶
ƣ |
η | Hygiene effectiveness relative to social distancing (unitless) | η | Beta(2,2) | ¶ |
τs | Duration of shelter in place (d) | τs | Validation: N(30, 30) [0, 90] Calibration: State-specific | 46 |
τr | Duration of linear increase after shelter-in-place (d) | τr | Validation: N(45, 30) [0, 105] Calibration: State-specific |
¶
ƣ |
rmax | Maximum relative increase in contacts from shelter-in-place (unitless) | rmax | Validation: Beta(2,2) Calibration: State-specific |
¶
ƣ |
τcase | Lag time for observing confirmed case | τcase | LogN(7, 2) [1, 14] | ¶ |
τdeath | Lag time for observing confirmed death | τdeath | LogN(7, 2) [1, 14] | ¶ |
αpos | Negative Binomial shape parameter for cases likelihood function | αpos | LogU(4, 40) | ¶ |
αdeath | Negative Binomial shape parameter for deaths likelihood function | αdeath | LogU(8, 40) | ¶ |
LogN(GM, GSD) = lognormal distribution with geometric mean GM and geometric standard deviation GSD
N(M,SD) = normal distribution with mean M and standard deviation SD
U(MIN,MAX) = uniform distribution with minimum MIN and maximum MAX
LogU(MIN, MAX) = log-uniform distribution with minimum MIN and maximum MAX
Time (t) is measured from t=1 corresponds to 2020-01-01.
Assumed, non-informative prior.
Standard contact tracing guidance is to self-isolate for 2 weeks.
For calibration to 6/20/20, state-specific priors were derived by fitting to different social distancing data sets, with each parameter’s mean, standard deviation, and range used to define a normal distribution prior.
See Methods for relationship between IFR and δ.