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[Preprint]. 2020 Jun 30:rs.3.rs-39128. [Version 1] doi: 10.21203/rs.3.rs-39128/v1

Figure 3.

Figure 3

(a) The heat map compares the MSigDB pathway signatures (ssGSEA) between the PBMCs of COVID-19 and healthy patients. COVID-19 patients have increased enrichment of glucose metabolism, glycolysis, Wnt signaling, Krebs cycle, proteasomes, p53 pathway, while the T-cell receptor (TCR), T helper, cytotoxic T lymphocyte (CTL) pathways have decreased enrichment. (b) In the heat map comparing the PBMCs of SARS and healthy patients, SARS patients have increased enrichment of cell cycle and tricarboxylic acid (TCA) cycle functions, while the TCR and CTL functions have decreased enrichment. (c) The scatter plot shows the log fold changes of differentially enriched pathway signatures in SARS vs. healthy and COVID-19 vs. healthy patients. The common pathway signatures highly enriched in both SARS- and COVID-19-infected patients (top right panel, purple) are androgen receptor, solute carrier transport, and potassium channel pathways, while the common immune signatures with low enrichment (bottom left panel, pink) are TCR, T-cell apoptosis, T helper, and CTL pathways.