Table 2.
Basal expression of Oral Epithelial Cell Interferon-Stimulated Genes
| ISG | High Base Mean | Rank of all transcripts (out of 23,557) | Inhibition | Expression Level | Viral Inhibitions |
|---|---|---|---|---|---|
| ZC3HAV1 (ZAP) | 5326.347284 | 1279 | Transcription | High | Entry, Transcription, Replication |
| OAS3 | 3785.979053 | 1765 | Replication/Transcription | ||
| SP100 | 2147.193058 | 2681 | Replication/Transcription | ||
| IFITM2 | 1694.801492 | 3095 | Entry | ||
| PML | 1622.004495 | 3185 | Replication/Transcription | ||
| IFIT2 | 1009.976154 | 3972 | Transcription | ||
| IFITM3 | 650.3736959 | 4725 | Entry | Medium | Viral Protein Function, Exit |
| ISG15 | 548.096075 | 4998 | Viral Protein Function | ||
| BST2 (Tetherin) | 465.888201 | 5239 | Exit | ||
| ISG20 | 397.6777008 | 5514 | Transcription | ||
| OAS2 | 305.0472818 | 5964 | Replication/Transcription | ||
| APOBEC3G | 248.470772 | 6332 | Replication/Transcription | ||
| IFITM1 | 245.6929232 | 6352 | Entry | ||
| OAS1 | 74.7362237 | 8733 | Replication/Transcription | Low | Post-entry, Pro-NK cell |
| TRIM5 | 54.19553982 | 9471 | Post-entry | ||
| MX2 | 52.96851709 | 9524 | Post-entry | ||
| ADAR | 43.92095899 | 9970 | Replication/Transcription | ||
| IFIT1 | 41.49804198 | 10135 | Transcription | ||
| OASL | 39.05579773 | 10295 | Replication/Transcription | ||
| RSAD2 (Viperin) | 27.16107836 | 11268 | Entry/Exit | ||
| MICB | 25.12520191 | 11495 | Pro-NK cell | ||
| MICA | 20.39141631 | 12106 | Pro-NK cell | ||
| EIF2AK2 (PKR) | 19.8998665 | 12169 | Translation | ||
| IFIT3 | 14.84120697 | 13109 | Transcription | ||
| MX1 | 13.41645478 | 13433 | Post-entry | ||
| CH25H | 6.15382301 | 16147 | Entry |
Basal expression levels of ISGs from OKF6/Tert-1 cells were measured by RNASeq analysis, ranked by high base mean (base mean of most highly expressed transcript variant of particular gene from three biological replicates), and grouped based on overall expression level.