Table 4.
Comparison of dosimetric parameters in normal organs-at-risk for left-side-breast cancer patients with irradiation of the whole breast/chest wall, the axillary (levels II and III) region, the supraclavicular field, and the internal mammary nodes by using different treatment techniques
| Technique | CB | CDCB0 | CDCB10 | CDCB15 | CDCB20 | OBDB | 5F-IMRT | p value | |
|---|---|---|---|---|---|---|---|---|---|
| Organs | Parameters | Mean ± SD | Mean ± SD | Mean ±S D | Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | |
| Ipsilateral lung | Mean (Gy) | 15.82 ± 1.82 | 14.03 ± 1.38 | 13.14 ± 1.41 | 12.78 ± 1.43 | 12.77 ± 1.29 | 15.07 ± 2.29 | 15.69 ± 1.54 | <0.001 |
| V5 (%) | 56.15 ± 3.95 | 58.29 ± 4.66 | 54.82 ± 4.04 | 54.10 ± 3.90 | 54.03 ± 3.95 | 84.14 ± 8.56 | 60.64 ± 5.93 | <0.001 | |
| V10 (%) | 48.02 ± 4.43 | 45.48 ± 4.26 | 42.80 ± 4.12 | 41.51 ± 4.01 | 41.67 ± 3.51 | 50.73 ± 11.71 | 43.97 ± 3.73 | <0.001 | |
| V20 (%) | 34.31 ± 4.88 | 27.80 ± 4.50 | 25.80 ± 4.41 | 24.80 ± 4.46 | 24.93 ± 4.07 | 26.56 ± 5.93 | 30.56 ± 4.02 | <0.001 | |
| Contralateral lung | Mean (Gy) | 1.10 ± 0.24 | 1.14 ± 0.20 | 1.21 ± 0.24 | 1.41 ± 0.24 | 1.64 ± 0.21 | 6.04 ± 0.79 | 0.87 ± 0.11 | <0.001 |
| V20 (%) | 0.15 ± 0.18 | 0.07 ± 0.06 | 0.10 ± 0.08 | 0.08 ± 0.08 | 0.10 ± 0.09 | 0.84 ± 0.77 | 0.13 ± 0.10 | <0.05 | |
| Contralateral breast | Mean (Gy) | 2.81 ± 1.54 | 2.81 ± 1.23 | 2.53 ± 1.33 | 2.53 ± 1.35 | 2.52 ± 1.34 | 4.56 ± 0.76 | 1.75 ± 0.99 | <0.001 |
| Heart | Mean (Gy) | 5.09 ± 1.30 | 5.68 ± 1.27 | 6.11 ± 1.31 | 6.20 ± 1.43 | 6.23 ± 1.40 | 10.41 ± 1.72 | 6.11 ± 1.36 | <0.001 |
| V5 (%) | 19.98 ± 5.67 | 30.23 ± 6.29 | 33.15 ± 7.20 | 33.70 ± 7.74 | 33.94 ± 7.60 | 88.81 ± 14.14 | 34.56 ± 14.45 | <0.001 | |
| V25 (%) | 5.07 ± 2.20 | 3.41 ± 1.76 | 3.59 ± 1.77 | 5.33 ± 5.0 | 5.37 ± 5.36 | 5.45 ± 2.57 | 4.72 ± 1.73 | <0.001 | |
| V30 (%) | 3.58 ± 1.67 | 2.11 ± 1.27 | 2.12 ± 1.18 | 2.14 ± 1.20 | 1.93 ± 1.16 | 3.49 ± 1.74 | 3.56 ± 1.47 | <0.001 | |
| V40 (%) | 1.47 ± 0.88 | 0.63 ± 0.57 | 0.67 ± 0.49 | 0.70 ± 0.51 | 0.55 ± 0.46 | 1.16 ± 0.72 | 1.56 ± 1.03 | <0.001 | |
| LAD | Mean (Gy) | 22.85 ± 6.36 | 18.44 ± 5.95 | 16.67 ± 5.52 | 16.31 ± 5.58 | 15.66 ± 5.26 | 11.83 ± 3.24 | 27.00 ± 9.63 | <0.001 |
| Maximum (Gy) | 45.49 ± 5.41 | 43.73 ± 6.56 | 40.66 ± 9.29 | 40.08 ± 10.12 | 39.70 ± 10.33 | 34.93 ± 9.07 | 47.70 ± 3.61 | <0.001 | |
CB, complete block; CDCB, complete-directional-complete block; 5F-IMRT, 5-field intensity- modulated radiotherapy; LAD, left anterior descending oronary artery; OBDB, organ-base-directional block; Vx, the volume of the organ receiving x Gy.
Data are presented as the mean ± standard deviation.