Table 1.
Characteristics of candidate gene International Clopidogrel Pharmacogenomics Consortium cohort
| Characteristics (units) | Male | Female | All |
|---|---|---|---|
| Number (N) | 2464 | 927 | 3391 |
| Age (years), mean ± SD | 60.8 ± 12.8 | 60.6 ± 15.7 | 60.8 ± 13.6 |
| BMI (kg/m2), mean ± SD | 27.3 ± 4.0 | 27.7 ± 5.1 | 27.4 ± 4.3 |
| Systolic blood pressure (mmHg), mean ± SD | 134.3 ± 23.1 | 127.9 ± 23.0 | 131.9 ± 23.3 |
| Diastolic blood pressure (mmHg), mean ± SD | 77.7 ± 12.2 | 73.5 ± 10.5 | 76.1 ± 11.7 |
| Hypertension,an (%) | 2142 (86.9) | 625 (67.4) | 2767 (81.6) |
| Total cholesterol (mg/dL), mean ± SD | 181.6 ± 49.9 | 205.3 ± 52.9 | 189.0 ± 52.0 |
| LDL-cholesterol (mg/dL), mean ± SD | 115.9 ± 42.9 | 130.3 ± 47.4 | 120.4 ± 44.9 |
| HDL-cholesterol (mg/dL), mean ± SD | 48.2 ± 14.8 | 59.6 ± 16.1 | 51.7 ± 16.1 |
| Triglycerides (mg/dL), mean ± SD | 130.5 ± 112.8 | 101.0 ± 66.8 | 121.3 ± 101.7 |
| Hypercholesterolaemia,bn (%) | 2216 (89.9) | 714 (77.0) | 2930 (86.4) |
| Taking aspirin, n (%) | 2309 (93.7) | 889 (95.9) | 3198 (94.3) |
| Taking statins, n (%) | 1734 (70.4) | 450 (48.5) | 2184 (64.4) |
| Taking PPI, n (%) | 538 (21.8) | 177 (19.1) | 715 (21.1) |
| Self-reported diabetes, n (%) | 449 (18.2) | 171 (18.3) | 620 (18.3) |
| Haematocrit ± SD (%) | 41.6 ± 4.0 | 37.9 ± 3.4 | 40.5 ± 4.2 |
| White blood cell count (n × 1000), mean ± SD | 7.2 ± 3.1 | 6.7 ± 2.5 | 7.1 ± 2.9 |
| Platelet count (n × 100 000), mean ± SD | 2.3 ± 0.7 | 2.5 ± 0.7 | 2.4 ± 0.7 |
| Ever smoker,cn (%) | 1444 (58.6) | 242 (26.2) | 1686 (49.7) |
| Current smoker,cn (%) | 485 (19.7) | 85 (9.2) | 570 (16.8) |
SI conversion factors: to convert HDL-cholesterol, LDL-cholesterol, and total cholesterol values to mmol/L, multiply by 0.0259; triglycerides to mmol/L, multiply by 0.0113.
BMI, body mass index; HDL, high-density lipoprotein; LDL, low-density lipoprotein; PPI, proton pump inhibitor; SD, standard deviation.
a
Defined as systolic blood pressure >140 mmHg, diastolic blood pressure >90 mmHg, taking prescription blood pressure-lowering medication, and/or source code for hypertension.
b
Defined as LDL-cholesterol >160 mm⋅mg/dL, taking prescription cholesterol-lowering medication, and/or source code for hypercholesterolaemia.
c
Self-reported history of smoking.