Table 2.

Association of candidate gene single nucleotide polymorphisms with adenosine diphosphate-stimulated platelet aggregation in International Clopidogrel Pharmacogenomics Consortium participants

Gene	Allele designation	rs number	Chromosome	MAF	HWE P-value	Beta	P-value	CYP2C19*2 adjusted P-value
CYP2C19	*2	rs4244285	10q23.33	0.163	0.084	0.506	8.80 × 10−54	NA
CES1	G143E	rs71647871	16q12.2	0.016	0.631	−0.787	1.30 × 10−16	4.27 × 10−18
CYP2C19	*17	rs12248560	10q23.33	0.219	0.755	−0.177	9.48 × 10−10	0.006
CYP2B6	1294 + 53C > T	rs8192719	19q13.2	0.229	0.013	0.105	2.99 × 10−4	1.15 × 10−4
CYP2B6	Q172H	rs3745274	19q13.2	0.215	0.032	0.099	9.98 × 10−4	3.53 × 10−4
CYP2C9	*2	rs1799853	10q23.33	0.151	0.022	−0.113	0.001	0.489
CYP2C9	*3	rs1057910	10q23.33	0.072	0.908	0.153	0.001	2.81 × 10−7
PEAR1	NA	rs12041331	1q23.1	0.123	0.005	−0.116	0.003	4.15 × 10−4
P2RY12	T744C	rs2046934	3q25.1	0.175	0.003	0.088	0.004	0.003
CES1	NA	rs2244613	16q12.2	0.206	1.000	0.080	0.007	0.006
MED12L	NA	rs1472122	3q25.1	0.480	0.715	−0.063	0.009	0.002
ITGB3	L59P	rs5918	17q21.32	0.150	0.437	−0.081	0.016	0.005
CYP2C19	*8	rs41291556	10q23.33	0.002	0.016	0.560	0.020	0.008
CYP2B6	485-18C > T	rs4803419	19q13.2	0.310	0.414	0.058	0.026	0.023
CYP2B6	14593C > G	rs4803418	19q13.2	0.306	0.444	0.056	0.038	0.033
CYP2B6	*1B	rs7254579	19q13.2	0.322	0.972	0.051	0.050	0.045
CYP2C19	*4	rs28399504	10q23.33	0.003	1.000	−0.488	0.065	0.197
CYP2C19	*3	rs4986893	10q23.33	0.001	1.000	0.709	0.107	0.071
POR	IVS11 + 20G > A	rs2286823	7q11.23	0.293	0.071	0.040	0.125	0.086
CYP2C9	*11	rs28371685	10q23.33	0.004	1.000	0.307	0.167	0.772
CYP2C19	*6	rs72552267	10q23.33	0.002	0.024	0.335	0.175	0.198
POR	*28	rs1057868	7q11.23	0.288	0.249	−0.032	0.234	0.240
POR	NA	rs2302429	7q11.23	0.145	6.41 × 10 − 5	−0.036	0.296	0.354
CYP2C19	*7	rs72558186	10q23.33	0.002	4.03 × 10 − 8	−0.248	0.332	0.585
CYP1A2	*1F	rs762551	15q24.1	0.317	0.648	−0.024	0.343	0.521
ABCB1	C1236T	rs1128503	7q21.12	0.408	0.875	0.021	0.405	0.318
PON1	L55M	rs854560	7q21.3	0.371	0.359	−0.019	0.456	0.617
CYP2C19	*5	rs56337013	10q23.33	2.32 × 10−4	1.000	−0.600	0.542	0.627
CYP3A5	*3F	rs28365085	7q22.1	2.31 × 10−4	1.16 × 10−4	0.163	0.741	0.621
PON1	Q192R	rs662	7q21.3	0.290	0.853	0.007	0.785	0.872
ABCB1	C3435T	rs1045642	7q21.12	0.496	0.107	0.007	0.786	0.614

Association P-values in bold represent those that are statistically significant after correction for multiple testing (P = 0.05/31 = 0.0016). Italicized Hardy–Weinberg P-values denote deviations from expected Hardy–Weinberg proportions (cut-off P-value <1.0 × 10⁻⁴).

HWE, Hardy–Weinberg equilibrium; MAF, minor allele frequency; NA, not applicable.