. Author manuscript; available in PMC: 2020 Jul 15.

Published in final edited form as: ACS Biomater Sci Eng. 2019 Nov 13;6(1):433–441. doi: 10.1021/acsbiomaterials.9b01384

Table 3.

Bactericidal action of gNO and COS-EA/NO against Pseudomonas aeruginosa and Staphylococcus aureus exposure under aerobic or anaerobic conditions for 5 h.^a

Bacteria species	NO exposure method	Aerobic exposure		Anaerobic exposure
Bacteria species	NO exposure method	MBC_5h	NO dose (μmol/mL)	MBC_5h	NO dose (μmol/mL)
P. aeruginosa	COS-EA/NO	0.20 mg/mL	0.09^b	0.39 mg/mL	0.17^b
P. aeruginosa	gNO	500 ppm	1.8^c	>800 ppm	n.q.^d
S. aureus	COS-EA/NO	3.12 mg/mL	1.37^b	0.78 mg/mL	0.34^b
S. aureus	gNO	>600 ppm	n.q.^d	>800 ppm	n.q.^d

All exposures performed in 10 mM PBS (pH 6.5, 37 °C).

Quantified using NOA.

Determined using amperometric sensor.

Not quantified; unable to quantify NO dose due to MBC requiring higher gNO concentration than our system could supply.