TABLE 3.
Novel Combinations for the Treatment of Older, Newly Diagnosed Adult Patients With Multiple Myeloma
| Treatment | Schedule |
|---|---|
| VMP77 | Nine 6-week cycles: |
| V: 1.3 mg/m2 days 1, 4, 8, 11, 22, 25, 29, 32 (cycles 1–4); and days 1, 8, 22, 29 (cycles 5–9) | |
| M: 9 mg/m2 days 1–4 | |
| P: 60 mg/m2 days 1–4 | |
| VMP weekly78,79 | Nine 5-week cycles: |
| V: intravenously 1.3 mg/m2 days 1, 8, 15, 22 | |
| M: 9 mg/m2 orally days 1–4 | |
| P: 60 mg/m2 orally days 1–4 | |
| VCd80 | Four 4-week cycles: |
| V: 1.3 mg/m2 intravenously days 1, 4, 8, 11 | |
| C: 300 mg/m2 orally days 1, 8, 15, 22 | |
| d: 40 mg orally days 1–4, 9–12, and 17–20 | |
| Dara-VMP40,81 | Nine 6-week cycles: |
| Dara 16 mg/kg days 1, 8, 15, 22, 29, 36 of cycle 1 and days 1, 22 of cycles 2–9, then every 4 weeks thereafter | |
| V: 1.3 mg/m2 days 1, 4, 8, 11, 22, 25, 29, 32 of cycle 1 and days 1, 8, 22, 29 of cycles 2–9 | |
| M: 9 mg/m2 days 1–4 | |
| P: 60 mg/m2 days 1–4 | |
| Rd82,83 | 4-week cycles, until PD: |
| R: 25mg/day days 1–21 | |
| d: 40 mg days 1,8,15,22 | |
| Rd-R84 | Induction: nine 4-week cycles: |
| R: 25 mg/day days 1–21 | |
| d: 20 mg days 1, 8, 15, 22 | |
| Maintenance, until PD: | |
| R: 10 mg/day for 21 days until PD | |
| VRd50,51 | Induction: eight 3-week cycles: |
| V: 1.3 mg/m2 intravenously (push) days 1, 4, 8, 11 | |
| R: 25 mg/day days 1–14 | |
| d: 20 mg/day days 1, 2, 4, 5, 8, 9, 11, 12 | |
| Maintenance: 4-week cycles until PD: | |
| R: 25 mg/day days 1–21 | |
| d: days 1, 8, 15, 22 | |
| Vrd lite85 | Induction: 5-week cycle: |
| v: 1.3 mg/m2 days 1, 8, 15, 22 | |
| r: 15 mg days 1–21 | |
| d: 20 mg days 1, 2, 8, 9, 15, 16, 22, 23 for patients age ≤ 75 years; days 1, 8, 15, 22 for patients age > 75 years | |
| Consolidation: 6-week cycles: | |
| v: 1.3 mg/m2 days 1,15 | |
| r: 15 mg days 1–21 | |
| Dara-Rd86 | Until PD: |
| Dara: 16 mg/kg (intravenously) every week for cycles 1 and 2, every other week for cycles 3–6, every 4 weeks thereafter | |
| R: 25 mg (oral) daily days 1–21 | |
| d: 40 mg (oral) days 1, 8, 15, 22 |
Abbreviations: C, cyclophosphamide; d, dexamethasone; Dara, daratumumab; M, melphalan; P, prednisone; PD, progressive disease; R, lenalidomide; V, bortezomib.