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. 2020 Jun 1;295(28):9712–9724. doi: 10.1074/jbc.RA119.012121

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© 2020 Liu et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 6. — Pcgf6 plays a key role in recruiting G9a/Glp and Hdac1/2 to germline-related genes. A, mRNA expression analysis of the selected genes in ESCs of the indicated genotype. B–D, ChIP-qPCR analysis showing enrichment of the indicated proteins on the selected gene promoters in WT and Pcgf6^−/− ESCs. Error bars, S.D. of three independent repeats. E, a schematic model showing that recruiting Hdac1/2 and G9a/Glp is an important mechanism used by Pcgf6 to modify histone tails and repress the expression of germline-related genes (see “Discussion” for a detailed description).