. 2018 Oct 12;2(4):NS20180139. doi: 10.1042/NS20180139

Table 4. microRNAs significantly affected in preeclampsia and by MitoQ-NP treatment.

microRNA	Known relevant functions
Up-regulated in PE
hsa-miR-561-5p	Regulates 11β-HSD1, which is highly expressed in liver, adipose tissue and CNS [96]
hsa-miR-561-5p	Associated with Parkinson’s disease [97]
hsa-miR-548ai+hsa-miR-570-5p	miR-570 associated with autism [98] and congenital heart disease [99]
hsa-miR-548ai+hsa-miR-570-5p	miR-570 regulates cytochrome P450 [100]
hsa-miR-196b-5p	Associated with ectopic pregnancy [101]
hsa-miR-196b-5p	Associated with endometriosis [102]
hsa-miR-2117	None
hsa-miR-3065-3p	None
Down-regulated in PE
hsa-miR-596	None
hsa-miR-451a	Associated with type 2 diabetes [103]

Listed are those microRNAs that were found to be up- or down-regulated in culture medium conditioned by preeclamptic placental explants, compared with healthy explants, and that were also affected in the opposite direction by treatment of the placenta with MitoQ-NPs but not blank-NPs.