Fig. 4.

A diagram of interaction energies between Remdesivir, nearby residues, and bases. The square frames represent RNA bases, and the rounded frames signify RdRp residues. The value beside each arrow represents an interaction energy value, with the unit of kcal/mol. The red lines specifically indicate stabilization by hydrogen bonding. The green lines indicate stabilization by π-π stacking interaction between -1U and -1A′ and stabilization by OH/π interaction with Thr687. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)