Table 2.
The Statistical data for morphologic analysis of the cerebellum in the cKO-PV and Ctrl mice
| Age | P14 | P21 | P30 | P60 | P120 | |
|---|---|---|---|---|---|---|
| The area of cerebellar middle sagittal sections (mm2) | Ctrl | 6.86 ± 0.07(n = 4) | 8.30 ± 0.09(n = 4) | 8.30 ± 0.16(n = 4) | 8.94 ± 0.18(n = 4) | 8.73 ± 0.39(n = 3) |
| cKO-PV | 6.64 ± 0.13(n = 3)ns | 7.35 ± 0.19(n = 4)* | 6.88 ± 0.15(n = 3)*** | 6.72 ± 0.22(n = 5)*** | 4.90 ± 0.34(n = 4)*** | |
| p value | >0.9999 | 0.0140 | 0.0005 | <0.0001 | <0.0001 | |
| The number of PCs per 100 μm length | Ctrl | 4.20 ± 0.10(n = 3) | 4.05 ± 0.14(n = 4) | 4.04 ± 0.06(n = 4) | 3.89 ± 0.08(n = 4) | 3.05 ± 0.17(n = 3) |
| cKO-PV | 3.96 ± 0.05(n = 3)ns | 4.35 ± 0.33(n = 4)ns | 4.34 ± 0.02(n = 4)ns | 4.53 ± 0.11(n = 5)ns | 1.70 ± 0.27(n = 3)*** | |
| p value | >0.9999 | >0.9999 | >0.9999 | 0.1903 | 0.0005 | |
| Total number of PCs in cerebellar lobule V | Ctrl | 79.74 ± 4.41(n = 4) | 59.75 ± 3.89(n = 3) | |||
| cKO-PV | 79.80 ± 4.51(n = 4)ns | 26.30 ± 4.56(n = 3)** | ||||
| p value | >0.9999 | 0.0012 | ||||
| Total number of PCs in cerebellar lobule VI | Ctrl | 82.61 ± 3.32(n = 4) | 60.83 ± 2.00(n = 3) | |||
| cKO-PV | 79.47 ± 1.55(n = 4)ns | 21.50 ± 4.73(n = 3)*** | ||||
| p value | 0.8988 | <0.0001 | ||||
| Area of PCs cell body (μm2) | Ctrl | 314.21 ± 15.79(n = 4) | 323.85 ± 3.26(n = 4) | 325.91 ± 11.21(n = 4) | 321.06 ± 8.07(n = 4) | |
| cKO-PV | 302.29 ± 15.10(n = 3)ns | 243.71 ± 13.88(n = 4)*** | 214.40 ± 4.47(n = 4)*** | 169.46 ± 5.33(n = 5)*** | ||
| p value | >0.9999 | <0.0001 | <0.0001 | <0.0001 | ||
| The ML thickness of the cerebellar lobule V (μm) | Ctrl | 102.20 ± 9.43(n = 4) | 144.73 ± 6.50(n = 3) | 152.23 ± 1.58(n = 4) | 167.49 ± 4.30(n = 4) | 158.08 ± 5.96(n = 3) |
| cKO-PV | 97.10 ± 3.99(n = 3)ns | 121.94 ± 3.82(n = 4)* | 127.71 ± 4.27(n = 4)** | 110.24 ± 3.66(n = 4)*** | 63.59 ± 2.05(n = 3)*** | |
| p value | >0.9999 | 0.0250 | 0.0072 | <0.0001 | <0.0001 | |
| The ML thickness of the cerebellar lobule VI (μm) | Ctrl | 112.27 ± 11.13(n = 4) | 163.44 ± 6.37(n = 3) | 181.08 ± 2.63(n = 4) | 196.98 ± 5.18(n = 4) | 188.18 ± 7.71(n = 3) |
| cKO-PV | 111.21 ± 6.58(n = 3)ns | 139.97 ± 5.76(n = 4)ns | 148.58 ± 2.36(n = 4)** | 128.78 ± 8.21(n = 4)*** | 72.72 ± 1.51(n = 3)*** | |
| p value | >0.9999 | 0.1030 | 0.0053 | <0.0001 | <0.0001 |
The data are the mean ± SEM.
***p < 0.001;
**p < 0.01;
*p < 0.05; ns, p ≥ 0.05.