Table 2.

Major disorders reported to have associations with increased NfL concentration in peripheral blood

Clinical condition	Key references
Ageing	Disanto et al., 2017; Mattsson et al., 2017; Barro et al., 2018
Peripheral neuropathies
CMT	Sandelius et al., 2018
Guillain-Barré syndrome	Petzold et al., 2006
Chronic inflammatory demyelinating polyneuropathy	van Lieverloo et al., 2019
Multiple sclerosis	Lycke et al., 1998; Malmestrom et al., 2003; Norgren et al., 2004; Teunissen et al., 2009; Gunnarsson et al., 2011; Kuhle et al., 2016b, 2017
ALS	Lu et al., 2015; Steinacker et al., 2016
Dementia
Preclinical Alzheimer’s disease	Weston et al., 2017, 2019; Preische et al., 2019
Alzheimer’s disease	Mattsson et al., 2017
Frontotemporal dementia	Meeter et al., 2016
Atypical parkinsonian disorders (e.g. progressive supranuclear palsy)	Rojas et al., 2016; Donker Kaat et al., 2018
Stroke
Subarachnoid haemorrhage	Nylen et al., 2006; Zanier et al., 2011
Ischaemic stroke	Gattringer et al., 2017
Traumatic brain injury	Shahim et al., 2016 , 2017
Huntington’s disease	Byrne et al., 2017; Johnson et al., 2018
Neuropsychiatric conditions
Bipolar disorder	Jakobsson et al., 2014
Spinal muscular atrophy	Darras et al., 2019