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. 2020 Jun 23;143(7):2255–2271. doi: 10.1093/brain/awaa154

Figure 2.

Figure 2

Increased gliosis and mild behavioural defects in TMEM106B-deficient mice. (A and B) Increased astrocyte activation in 5-month-old Tmem106b−/− (Δ341bp) mice. Brain sections were stained with anti-GFAP or IbaI antibodies, and images were captured in hippocampus region. Scale bar = 10 µm. n = 3 (two females, one male each genotype), ***P < 0.001, Student’s t-test. (C–F) Western blot analysis of GFAP and Iba1 protein levels in wild-type and Tmem106b−/− frontal cortex lysates (C and D: 5 months old, Δ341bp; E and F: 10 months old, Δ7bp). n = 4 (two females, two males each genotype), *P < 0.05, paired t-test with littermate wild-type controls. (G–I) Tmem106b−/− mice show normal behaviour in the open field test (G) and rotor rod test (H), but show a slight delay in passing balance beam (I). n = 12–17 (male), 10–12 (female); *P < 0.05, Student’s t-test. KO = knockout; WT = wild-type.