Table 3.
Multiple linear regression models with significant results using average cytokine levels
| Unadjusted β [95% CI] | p-value | R2 | Adjusted β1 [95% CI] | p-value | R2 | β1 [95% CI] | p-value | R2 | |
|---|---|---|---|---|---|---|---|---|---|
| NAPI MDV | |||||||||
| TNF-α | −0.16 [−0.42, 0.12] | 0.26 | 0.018 | −0.11 [−0.35, 0.15] | 0.41 | 0.087 | −0.33 [−0.60, −0.06] | 0.018 | 0.11 |
| TNF-α*PMA | 0.03 [−0.02, 0.08] | 0.3 | |||||||
| TNF-α*sex | −0.04 [−0.74, 0.67] | 0.92 | |||||||
| IL-1RA | −0.42 [−0.70, −0.16] | 0.002 | 0.13 | −0.37 [−0.64, −0.08] | 0.013 | 0.16 | −0.61 [−1.05, −0.16] | 0.008 | 0.18 |
| IL-1RA*PMA | 0.02 [−0.03, 0.07] | 0.38 | |||||||
| IL-1RA*sex | 0.01 [−0.49, 0.52] | 0.96 | |||||||
| NAPI AO | |||||||||
| IL-6 | 0.09 [0.02, 0.15] | 0.01 | 0.009 | 0.11 [0.03, 0.20] | 0.011 | 0.068 | 1.29 [0.005, 2.52] | 0.049 | 0.13 |
| IL-6*PMA | −0.11 [−0.25, 0.02] | 0.09 | |||||||
| IL-6*sex | 0.49 [−1.31, 2.35] | 0.59 | |||||||
| TNF-α | −0.02 [−0.19, 0.15] | 0.78 | 0.0006 | 0.01 [−0.17, 0.20] | 0.88 | 0.054 | 0.22 [0.01, 0.42] | 0.042 | 0.11 |
| TNF-α*PMA | −0.03 [−0.07, 0.01] | 0.13 | |||||||
| TNF-α*sex | 0.15 [−0.39, 0.70] | 0.58 |
Note.
Adjusted for length of stay. NAPI, Neurobehavioral Assessment of the Preterm Infant; MDV, motor development and vigor; AO, alertness/orientation; TNF-α, tumor necrosis factor-alpha; IL-1RA, interleukin-1 receptor antagonist; PMA, post-menstrual age; β = standardized regression coefficient; CI, confidence interval; R2 = variance explained by model.