Table 2:
GO Cellular Components Associated with NAFLD Genes
| PANTHER GO-Slim Cellular Component | P value |
|---|---|
| GO Lipid droplet | |
| CIDEC (cell death activator CIDE-3) | 1.55 E-06 |
| ABHD5 (abhydrolase domain containing 5) | |
| PNPLA2 | |
| HILPDA (hypoxia-inducible lipid droplet-associated protein) | |
| PLIN4 (perilipin-4) | |
| CIDEB (cell death activator CIDE-B) | |
| CIDEA (cell death activator CIDE-A) | |
| PNPLA3 | |
| HSD17B13 (hydroxy steroid 17-beta dehydrogenase 13) | |
| GO Protein kinase complex | |
| CHUK (inhibitor of nuclear factor kappa-B kinase subunit alpha) | 3.57 E-04 |
| IGF1R (insulin-like growth factor 1 receptor) | |
| PRKAB1 (5’-AMP-activated protein kinase subunit beta-1) | |
| TGFBR1 (TGF-beta receptor type-1) | |
| PRKAB2 (5’-AMP-activated protein kinase subunit beta-2) | |
| INSR (insulin receptor) | |
| IKBKB (inhibitor of nuclear factor kappa-B kinase subunit beta) | |
| RNA polymerase II transcription II factor complex | |
| NR5A2 (nuclear receptor subfamily 5 group A member 2) | 1.03 E-06 |
| PPARG (peroxisome proliferator-activated receptor gamma) | |
| VDR (vitamin D3 receptor) | |
| NR1I2 (nuclear receptor subfamily 1 group I member 2) | |
| RARA (retinoic acid receptor alpha) | |
| PPARD (peroxisome proliferator-activated receptor delta) | |
| NR1H2 (oxysterols receptor LXR-beta) | |
| NR1H3 (oxysterols receptor LXR-alpha) | |
| PPARA (peroxisome proliferator-activated receptor alpha) | |
| NR1H4 (FXR, bile acid receptor) | |
| E2F1 (transcription factor E2F1) | |
| NR1I3 (nuclear receptor subfamily 1 group I member 3) | |
| NR1D2 (nuclear receptor subfamily 1 group D member 2) | |
| Nuclear lumen | |
| OAS1 (2’−5’-oligoadenylate synthase 1 | 8.02 E-04 |
| TP53 (cellular tumor antigen p53) | |
| NFKB1 (nuclear factor NF-kappa-B p105 subunit) | |
| MSL2 (E3 ubiquitin-protein ligase MSL2) | |
| ADARB2 (double-stranded RNA-specific editase B2) | |
| JUN (Transcription factor AP-1) | |
| SPTY2D1 (protein SPT2 homolog) | |
| ZPR1 (zinc finger protein ZPR1) | |
|
Cytoskeleton | |
| PARVB (beta-parvin) | 1.64 E-04 |
| DLG4 (lethal(2) giant larvae protein homolog 1) | |
| WDR1 (WD repeat-containing protein 1) | |
| ALMS1 (Alstrom syndrome protein 1) | |
| ADD1 (alpha-adducin) | |
| DNAH11 (dynein heavy chain 11, axonemal) | |
| MYO1B (unconventional myosin-Ib) | |
| SLC27A4 (long-chain fatty acid transport protein 4) | |
| ADD3 (gamma-adducin) | |
| Nuclear transcription factor complex (GO:0044798) | 1.24E-04 |
| Extracellular space (GO:0005615) | 8.39E-17 |
| Extracellular region part (GO:0044421) | 2.03E-17 |
| Extracellular region (GO:0005576) | 1.01E-18 |
| Intracellular (GO:0005622) | 6.08E-04 |
| Cell part (GO:0044464) | 2.72E-04 |
| Cell (GO:0005623) | 3.69E-04 |
| Microtubule cytoskeleton (GO:0015630) | 4.82E-05 |
We used PANTHER GO-slim updated with 512 cellular component terms