Figure 5.
Summary of effects and comparison with other models of schizophrenia pathophysiology/risk. Local field potential, cellwise, pairwise, and ensemblewise effects are summarized with up-arrows signifying an increase, down-arrows a decrease, left/right arrows a change in distribution, and squares no change. Deficits are the most consistent across models and conditions at the level of ensemble function. *Stimulus-evoked changes in gamma in Setd1a+/− mice affected high-gamma rather than low/mid-gamma as seen in other models. #Changes in pairwise correlations were spatial in Setd1a+/− mice, not distributional. Distributional changes were not observed in Setd1a+/− mice. spont., spontaneous. [Adapted from Hamm et al. (14).]