TABLE 1.

Summary of cardiac abnormalities in global and NC-specific mutant mice for Foxc1 and Foxc2

		Penetrance values disorders
Genotype	Time point	PTA	VSD	PTA;VSD	None	Genetic background	Reference
Foxc1 mutation
Global Foxc1−/−	P0 (n = 11)	0%	73%	0%	27% mixed		Winnier et al., 1999
NC-Foxc1-KO	E14.5 (n = 3)	0%	33%	0%	66%	Mixed	This paper
Foxc2 mutation
Global Foxc2−/−	P0	+				C57BL/6	Iida et al., 1997
	E13.5/E16.5 (n = 9)	0%	44%	0%	56%	Mixed	Winnier et al., 1999
	E12.5	+	+			129 s6/SvEv	Inman et al., 2018
NC-Foxc2-DKO	E11.5 (n = 4)	0%	0%	0%	100%	Mixed	This paper
	E14.5 (n = 7)	0%	0%	0%	100%	Mixed	This paper
Foxc1;Foxc2 mutation
Global Foxc1+/−;Foxc2−/−	E11.5	+				Mixed	Seo et al., 2006
NC-Foxc1;Foxc2-DKO	E11.5 (n = 3)	33%	0%	0%	67%	Mixed	This paper
	E14.5 (n = 5)	40%	20%	20%	20%	Mixed	This paper
NC-Foxc1;Foxc2-DKO;mTmG	E14.5 (n = 4)	100%	0%	0%	0%	Mixed	This paper