FIGURE 7.

FLPK modulates intrinsic excitability and persistent sodium current of MSNs in the NAc. (a) representative traces of action potentials (AP) evoked at a current step of 180 pA in MSNs treated with either 0.1% DMSO (black) or 50 μM FLPK (magenta). (b) average action potential count at varying injected current stimuli recorded in MSN in response to 0.1% DMSO (black) or 50 μM FLPK (magenta). (c) average instantaneous firing frequency (IFF) at varying injected current stimuli recorded in MSN in response to 0.1% DMSO (black) or 50 μM FLPK (magenta). (d) rrepresentative traces of MSN I _NaP elicited by application of slow voltage ramps (50 mV/s) in the presence (right) or absence (left) of FLPK (50 µM). I _NaP was isolated by digital subtraction of responses obtained in the presence of 0.5 μM TTX from those recorded under control conditions. (e) summary bar graph showed the experimental groups in d). Data are mean ± SEM (n = 7–14); *p < .05, ***p < .001; Student's t test and Mann–Whitney Test