TABLE 3.

Effect of FLPK on Nav1.6‐mediated currents in the presence of FGF14 or ΔNT‐FGF14

Condition	Peak density	Activation	Kact	Steady‐state Inactivation	Kinact	Tau (τ)
	pA/pF	mV	mV	mV	mV	ms
GFP (DMSO)	−58.6 ± 13.9 (15)	−21.8 ± 1.3 (12)	4.3 ± 0.2 (12)	−58.9 ± 0.8 (14)	5.8 ± 0.4 (14)	1.0 ± 0.08 (15)
GFP (FLPK)	−80.8 ± 12.2 (14)	−20.5 ± 1.2 (12)	3.9 ± 0.3 (12)	−59.3 ± 1.9 (10)	6.1 ± 0.5 (10)	0.8 ± 0.03 (12)r
FGF14‐GFP (DMSO)	−16.8 ± 3.3 (19) a,b	−16.6 ± 1.0 (10) d , e	5.7 ± 0.4 (10) f,g	−54.9 ± 1.1 (8) j	5.9 ± 0.9 (8)	1.7 ± 0.4 (10) k
FGF14‐GFP (FLPK)	−49.6 ± 7.2 (21) c	−20.8 ± 1.5 (11)	5.7 ± 0.5 (11) h,i	−59.2 ± 2.1 (11)	5.9 ± 0.6 (14)	1.3 ± 0.2 (11)
ΔNT‐FGF14‐GFP (DMSO)	–108 ± 18.4 (17) n	–21.2 ± 0.36 (14)	4.61 ± 0.3 (14)	–70.2 ± 0.53 (13) o,p,q	6.4 ± 0.44 (13)	1.091 ± 0.07 (15)
ΔNT‐FGF14‐GFP (FLPK)	−126.04 ± 12.3 (11) m , NS	–37.43 ± 0.3 (11) l , o,p,q	1.63 ± 0.23 (11)	–68.3 ± 0.34 (11) o,p,q	6.75 ± 0.32 (11)	1.137 ± 0.08 (11)

Data are mean ± SEM.

^a,b p < .001, one‐way ANOVA, post hoc Dunn test compared with GFP (DMSO) and (FLPK).

^c p < .05, unpaired t tests compared to FGF14‐GFP (DMSO).

^d p < .01, one‐way ANOVA, post hoc Fisher's LSD compared with GFP (DMSO).

^e p < .05, one‐way ANOVA, post hoc Fisher's LSD compared with GFP (FLPK).

^f,g p < .01, one‐way ANOVA, post hoc Fisher's LSD compared with GFP (DMSO) and (FLPK).

^h,i p < .01, one‐way ANOVA, post hoc Fisher's LSD compared with GFP (DMSO) and (FLPK).

^j p < .05, unpaired t tests compared to GFP (DMSO).

^k p < .05, one‐way ANOVA, post hoc Dunn test compared with GFP (DMSO).

^l p < .001, unpaired t tests compared to FGF14‐ΔNT‐GFP (DMSO).

^m p < .001, unpaired t tests compared to Nav1.6‐GFP (DMSO).

ⁿ p < .05, unpaired t tests compared to Nav1.6‐GFP (DMSO).

^o,p,q p < .001, unpaired t tests compared to Nav1.6‐GFP (DMSO).

^r p = .0495, unpaired t tests compared to Nav1.6‐GFP (DMSO).

^NS p < .5, unpaired t tests compared to FGF14‐ΔNT‐GFP (DMSO).