Figure 2.

Immunohistochemistry characterization of interstitial inflammatory infiltrate of patients 1 (a–f) and 2 (g–l). Patient 1 showed minimal scattered interstitial infiltrate, composed mainly of B lymphocytes (b) and macrophages (c); patient 2 showed focal moderate interstitial inflammation with abundant presence of plasma cells (j) and macrophages (i); both T (g) and B (h) lymphocytes were present. (a,g) CD3 (T-lymphocytes; original magnification ×100); (b,h) CD20 (B-lymphocytes; original magnification ×100); (c,i) CD163 (macrophages; original magnification ×100); (d,j) CD138 (plasma cells; original magnifications: d, ×100; j, ×200); (e,k) kappa light chain (original magnification ×100); and (f,l) lambda light chain (original magnification ×100).