Table II.
Results of laboratory imaging studies on admission to PICU
| Variables | Total (n = 70) | No ARDS (n = 49) | ARDS (n = 21) | P value∗ |
|---|---|---|---|---|
| WBC, k/μL, median (IQR) [n = 69] | 8.8 (6.3, 13.0) | 8.8 (6.3, 11.7) | 8.9 (6.0, 14.3) | .9105 |
| Absolute lymphocyte count, cells/μL, median (IQR) [n = 69] | 1117.4 (610.9, 1998.4) | 1001.6 (604.5, 2258.7) | 1177.0 (766.3, 1914.9) | .3936 |
| Hemoglobin, g/dL, median (IQR) [n = 69] | 12.2 (10.8, 14.6) | 12.9 (11.1, 14.7) | 11.9 (9.6, 13.2) | .1815 |
| Platelets, k/μL, median (IQR) [n = 69] | 198.0 (147.0, 264.0) | 216.0 (159.0, 309.0) | 169.0 (110.0, 242.0) | .0430 |
| AST, U/L, median (IQR) [n = 60] | 36.0 (28.0, 60.0) | 33.0 (27.0, 57.0) | 40.0 (32.0, 61.0) | .3691 |
| ALT, U/L, median (IQR) [n = 60] | 26.0 (14.5, 49.5) | 30.0 (15.0, 56.0) | 20.0 (12.0, 45.0) | .1870 |
| Total bilirubin, mg/dL, median (IQR) [n = 60] | 0.4 (0.2, 0.9) | 0.4 (0.2, 1.0) | 0.3 (0.1, 0.9) | .1987 |
| BUN, mg/dL, median (IQR) | 11.0 (8.0, 14.0) | 10.0 (8.0, 13.0) | 11.0 (7.0, 15.0) | .6528 |
| Creatinine, mg/dL, median (IQR) | 0.7 (0.5, 0.9) | 0.7 (0.5, 0.9) | 0.6 (0.4, 0.9) | .7728 |
| C-reactive protein, mg/dL, median (IQR) [n = 48] | 6.8 (2.6, 14.9) | 6.0 (2.5, 26.0) | 8.1 (3.5, 11.8) | .8716 |
| Procalcitonin, ng/mL, median (IQR) [n = 34] | 0.2 (0.1, 0.9) | 0.2 (0.1, 0.6) | 0.4 (0.2, 1.1) | .1778 |
| Pro-BNP, pg/mL, median (IQR) [n = 14] | 940.0 (92.0, 4289.0) | 440.8 (60.0, 4289.0) | 1734.0 (1112.0, 15 000.0) | .1195 |
| Troponin, ng/mL, median (IQR) [n = 32] | 0.0 (0.0, 0.0) | 0.0 (0.0, 0.0) | 0.0 (0.0, 0.1) | .6109 |
| CPK, U/L, median (IQR) [n = 25] | 120.0 (74.0, 302.0) | 128.5 (74.0, 316.0) | 99.0 (60.0, 302.0) | 1.0000 |
| Lactate, mmol/L, median (IQR) [n = 43] | 1.5 (1.2, 2.5) | 1.6 (1.2, 2.6) | 1.5 (1.3, 2.3) | .5972 |
| D-dimer, μg/mL FEU, median (IQR) [n = 35] | 2.3 (0.8, 161.0) | 3.1 (0.8, 161.0) | 2.0 (0.7, 20.0) | .8663 |
| LDH, U/L, median (IQR) [n = 39] | 370.0 (289.0, 524.0) | 318.0 (276.0, 461.0) | 421.0 (344.0, 569.0) | .0413 |
| IL-6, pg/mL, median (IQR) (n = 23) | 42 (13.7, 112) | 16.4 (12.1, 66) | 78.7 (34, 201.5) | .0316 |
| +Blood culture, n (%) | 8 (11.8) | 4 (8.5) | 4 (19.0) | .2403 |
| +Respiratory culture, n (%) | 3 (5.2) | 0 (0.0) | 3 (14.3) | .0431 |
| +Urine culture, n (%) | 5 (8.2) | 1 (2.5) | 4 (19.0) | .0437 |
| Chest radiograph | ||||
| Clear, n (%) | 12 (17.1) | 12 (24.5) | 0 (0.0) | .0133 |
| B/L infiltrates, n (%) | 35 (50.0) | 20 (40.8) | 15 (71.4) | .0189 |
| Pleural effusions, n (%) | 4 (5.7) | 1 (2.0) | 3 (14.3) | .0776 |
| Pneumothorax, n (%) | 1 (1.4) | 0 (0.0) | 1 (4.8) | .3000 |
| Other, n (%) | 16 (22.9) | 10 (20.4) | 6 (28.6) | .5383 |
| LV dysfunction by echocardiogram, n (%) | 6 (40.0) | 3 (33.3) | 3 (50.0) | .6224 |
| LV EF percentage, median (IQR) [n = 3] | 44.1 (25.0, 48.7) | 48.7 (48.7, 48.7) | 34.6 (25.0, 44.1) | .5403 |
| RV dysfunction by echocardiogram, n (%) [n = 3] | 3 (20.0) | 2 (22.2) | 1 (16.7) | 1.0000 |
ALT, alanine aminotransferase; AST, aspartate aminotransferase; B/L, Bilatera; BUN, blood urea nitrogen; CPK, creatine phosphokinase; EF, ejection fraction; FEU, Fibrinogen equivalent unit; IL, interleukin; LV, left ventricular; pro-BNP, pro-B type natriuretic peptide; LDH, lactate dehydrogenase; RV, right ventricular; WBC, white blood cell count.
∗
χ2 test, Fisher exact test, or Wilcoxon rank-sum test.