Fig. 1.

Study Hypothesis. Intake of a high in taurine and saturated fat diet increases liver bile acid secretion and production of taurine conjugated bile acids. Metabolism of the taurine conjugated bile acid TCA by Bilophila wadsworthia and Clostridium scindens yield both a carcinogen (H₂S) and a tumor-promoter (DCA), respectively [15]. Altering dietary intake of taurine and saturated fat may modulate bile acid composition, abundance of TCA metabolizing bacteria, and consequently markers of CRC risk.