Table 1.

Participant eligibility criteria.

Inclusion criteria:

•African American

•Body mass index (BMI) 25–50 kg/m2

•45–75 years of age

•Diagnosed with adenomatous colorectal polyps within 10 years

•C-reactive protein >3 mg/L

•Good general health

•Expect no major lifestyle changes in 6 months

•Willing to maintain current level of activity

•Women: Post-menopausal (natural or surgical)

Exclusion criteria:

•Race other than African American

•BMI <25 or >50 kg/m2

•Weight > 450 lbs

•Current malignancy except removed non-melanoma skin cancer

•Current gastrointestinal illness other than GERD or hemorrhoids

•Chronic liver or kidney disease

•History of cardiac disease

•Positive genetic test for inherited polyposis syndromes

•Inflammatory/auto-immune or connective tissue diseases

•Prior perforation at colonoscopy

•Gastrointestinal bleeding due to biopsies of the colon

•Alcoholism or illicit drug use in the past 5 years

•Marijuana use more than twice per week

•Antibiotic use within the past 2 months

•Regular medication use that may interfere with normal digestion

•Anticoagulant use

•Pre- or probiotics use within the past month

•Non-English speaking

•Therapeutic or vegetarian diet

•Women: at least one menstrual period in the past 6 months

•Women: Pregnant or breast feeding

•History of intestinal cancer, inflammatory bowel disease, celiac disease, or malabsorptive bariatric surgery

•Food allergies or other dietary restrictions

•Claustrophobia (due to RMR)