Table 1.

Diagnostic criteria 2012 International Tuberous Sclerosis Complex Consensus Conference.

MAJOR CRITERIA
Facial angiofibromas (≥3) or fibrous cephalic plaque	Cortical tuber	Cardiac rhabdomyoma
Nontraumatic ungual or periungual fibroma (≥2)	Subependymal nodule	Lymphangioleiomyomatosis:
Hypomelanotic macules (>3) at least 5 mm diameter	Subependymal giant cell astrocytoma	Renal angiomyolipoma
Shagreen patch	Multiple retinal hamartoma
MINOR CRITERIA
Multiple randomly distributed pits in dental enamel	Cerebral white matter radial migration lines	Retinal achromic patch
Hamartomatous rectal polyps	Intra oral fibroma	Confetti” skin lesions
Bone cysts	Nonrenal hamartoma	Multiple renal cysts

Definite TSC - Two major features or one major feature plus two or more minor features.