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. 2020 Apr 21;10(3):451–466. doi: 10.1016/j.jcmgh.2020.04.009

Figure 4.

Figure 4

Prolonged bile acid signaling by NTCP inhibition reduces body weight and adiposity in obese mice. Total plasma bile acid levels 3 hours after placebo or Myrcludex B (2.5 μg/g) injection and after (A) a 4- to 5-hour fast, (B) body weight change, and (C) adipose tissue weights of female HFD-fed Oatp1a/1b KO-h1B1 mice treated daily with placebo or Myrcludex B for 3.5 weeks (n = 10). (D) Hepatic TG content by representative images of liver histology by hematoxylin and eosin (H&E) (top) and Oil Red O (bottom) staining and (E) quantified Oil Red O staining (n = 4 images/mouse, 10 mice/group). (F) Fasting plasma GLP-1 levels and (G) plasma insulin levels, 0 and 15 minutes after an oral glucose bolus (2 g/kg) of the mice described in panel A. Error bars show SEM, asterisk indicates significant changes. gWAT, gonadal white adipose tissue; sWAT, subcutaneous white adipose tissue.