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Targeting COX-2/PGE2 partially reversed PM-induced downregulation of Filaggrin. a HBECs were pretreated with specific molecular inhibitors of COX-2 and PGE2 receptor then stimulated with PM. The protein expression of Filaggrin was measured by western blotting. The optical densities of protein bands are illustrated in b and c. Values represent means ± SD, *P < 0.05 or **P < 0.01, compared with the vehicle group; #P < 0.05 or ##P < 0.01, compared with the PM group; n = 3
