Fig. 2.

The diagnosis potentials of miR-221/222 in aggressive PTC (APTC). The Receiver operating characteristic (ROC) curves were constructed using the expression of miR-221/222 to determine the diagnostic potential of miR-221/222 in PTC (n = 40) and APTC (n = 47). AUC for miR-221/222 demonstrates accuracy in terms of sensitivity and specificity in APTC. The ROC curve yielded a miR-221/222 area under the ROC curve (AUC) value higher in APTC, compared to PTC (the AUC value of miR-221 was 0.660, and that of miR-222 was 0.803). The optimal cutoff value of miR-221 was 0.0087 (sensitivity, 80.74%; specificity, 74.8%) and that of miR-222 was 0.251 (sensitivity, 78.3%; specificity, 73.2%) in APTC. (Red and green represent APTC and PTC, respectively.)