Table 4.

Correlation of miR-221/222 with clinicopathological phenotypes of patients with PTC

Clinicopathological feature	Number	miR-221 level (mean ± SD)	P value	miR-222 level (mean ± SD)	P value
Age(year)
< 45	35	3.55 ± 0.63	0.625	2.79 ± 1.10	0.018
≥ 45	52	3.72 ± 1.98		3.17 ± 0.25
Size(cm)
≤ 1	30	2.97 ± 0.18	< 0.0001	2.36 ± 0.52	< 0.0001
> 1	57	3.94 ± 0.68		3.34 ± 0.73
TNM stage (AJCC)
I + II	43	2.30 ± 0.96	< 0.0001	2.36 ± 0.52	< 0.0001
III + IV	44	3.30 ± 0.61		2.85 ± 0.44
Mulifocality
Yes	51	3.53 ± 0.12	< 0.0001	3.36 ± 0.50	< 0.0001
No	36	3.04 ± 0.55		2.82 ± 0.62
Lymph node (LN) metastasis
Yes	49	3.59 ± 0.63	< 0.0001	3.86 ± 0.41	< 0.0001
No	38	2.60 ± 0.63		2.78 ± 0.64
Extra-thyroidal extension
Yes	47	4.88 ± 0.98	< 0.0001	4.56 ± 0.76	< 0.0001
No	40	2.57 ± 0.86		2.17 ± 0.75