TABLE 1.

Characteristics of Enhanced SC-β cell protocols.

Article	Format	Reaggregation	Sorting	Endocrine	SC-β Cell	1st Phase stimulation	2nd Phase stimulation	Return to baseline insulin secretion at low glucose	Insulin content μ IU insulin/1,000 cells
Velazco-Cruz et al., 2019	S	Yes	n/a	>95%	52%	7.6	2.1	Yes	321
Veres et al., 2019	S	Yes	CD49A + S6	>95%	80%	3.2	1.5	No	N.R.
Nair et al., 2019	S	Yes	INS:GFP S6	>99%	80%	3.5	1	n/a	N.R.
Hogrebe et al., 2020	P	Yes	n/a	>95%	31%	9.4	1.9	Yes	150
Mahaddalkar et al., 2020	S	Yes	CD177 + S1	N.R.	62%	5	1.15	n/a	317

Quantitative values estimated from graphs when not reported in text. N.R., not reported; S, suspension; P, planar; S#, stage #.