Figure 4.

Local adaptive and innate immune response after 1 week from the implantation. CD68+ and CD163+ macrophages were particularly abundant in the xenogeneic group, especially in the spheroids infiltration. No differences were evident in CD206+ macrophages distribution whereas more iNOS + cells were infiltrating the cartilaginous spheroids. CD3+ lymphocytes were predominant in the osteotomy gap of the xenogeneic samples compared to the other groups. Brown color indicates the positive staining. i, tissue infiltration; c, cartilaginous spheroids; g, collagen gel.