Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jul 9;8:651. doi: 10.3389/fbioe.2020.00651

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Longoni, Pennings, Cuenca Lopera, van Rijen, Peperzak, Rosenberg, Levato and Gawlitta.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

T lymphocyte reaction to the non-autologous implants after 12 weeks. (A) Proliferation of the T cells isolated from the draining lymph nodes was assessed in a co-culture model with the donor cells. Specific proliferation induced by the donor cells was observed only in the xenogeneic group. Nil: lymphocytes that were not exposed to any other cell type; Aspecific: lymphocytes co-cultured with third-party Sprague Dawley MSCs; *p < 0.05; **p < 0.01. (B) CD3+ T lymphocytes (indicated by the arrows) were still prominent in the local immune response against the xenogeneic implants. Fewer CD3+ cells were spotted in the collagen and allogeneic samples. Brown color indicates the positive staining; i, tissue infiltration; b, bone; c, cartilaginous construct; *EBR.