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. 2020 Jul 9;8:538. doi: 10.3389/fcell.2020.00538

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Copyright © 2020 Liu, Hu, Li, Zhang, Wu, Liu, Wang, Zhang and Jiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relationship between risk scores of the ferroptotic signature and autophagy. (A–C) In the CGGA database, correlation analysis of ferroptosis-related gene risk scores and autophagy markers (A, SQSTM1, MAPLC3C, BECN1, and ATG9B), apoptosis markers (B, CASP3, BCL2, BAX, and BAK1), and immune checkpoint markers (C, PD-1, TIM3, LAG3, and B7-H3). (D) Western blot analysis showing the expression levels of LC3 PARP and its cleaved-PARP, and PD-L1 in U251 and U87 glioblastoma cell lines treated with erastin (50 μM for 24 h). Data are presented as mean ± SEM. *P < 0.05 compared with respective controls.